Home  >  Products  >  Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909)
Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909)

Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909)

Cat no: N2567-38

Supplier: United States Biological
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A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax. Solubility: DMSO (50mM) Molecular Weight: ~466.52 Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: N2567-38
Size: 5mg
Form: Supplied as a white to off-white solid.
Purity: ~98% (TLC)
References: 1. Gupta, S.C., et al. (2011). J. Biol. Chem., 286, 1134-1146.

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