Home  >  Products  >  Nkx 2.5 (NKX2.5, NKX2-5, Homeobox Protein Nkx-2.5, Cardiac-specific Homeobox, CSX, CSX1, CHNG5, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, NKX2E, NKX4-1)
Nkx 2.5 (NKX2.5, NKX2-5, Homeobox Protein Nkx-2.5, Cardiac-specific Homeobox, CSX, CSX1, CHNG5, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, NKX2E, NKX4-1)

Nkx 2.5 (NKX2.5, NKX2-5, Homeobox Protein Nkx-2.5, Cardiac-specific Homeobox, CSX, CSX1, CHNG5, Homeobox Protein CSX, Homeobox Protein NK-2 Homolog E, NKX2E, NKX4-1)

Cat no: N2850-18F

Supplier: United States Biological
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NKX2.5 is a member of the NKX homeobox transcription factor family. NKX2.5 plays an essential role in heart development and is among the earliest factors expressed in cardiac lineage of developing embryos. Its targeted disruption in mice causes abnormal heart morphogenesis, severe growth retardation, and embryonic lethality around E9.5. Defects in NKX2.5 is associated with several forms of congenital heart diseases, such as atrial defect with atrioventricular conduction defects (ASD-AVCD) and tetralogy of Fallot (TOF). Transcription activation of NKX2.5 is also associated with certain B and T cell leukemias resultant from chromosomal translocation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.3-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N2850-18F
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien KR, Kasahara H. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circulation research 2008 Sep 103(6):580-90.
Additional info: Recognizes human CSX1. Species Crossreactivity: Mouse and rat. Species sequence homology: Bovine and canine.

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