NMDA 2b Receptor phosphorylated (Ser1303)

The NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. NMDA R1 and combination of one or more NMDAR2 subunits forms NMDA receptor glutamate-gated ion channels. In this hetromer complex, NMDA R1 binds to co-agonist glycine and NMDA R2 binds to neurotransmitter glutamate (1). Several studies have suggested that protein phosphorylation of NMDA receptors may affect channel function, and additionally regulate these receptors

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SPECIFICATIONS

Catalog Number

N2905-06A

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1. Tingley WG, et al. Nature 364(6432): 70-3, 1993 2. Strack S, McNeill RB, Colbran RJ. JBC 275(31):23798- 806, 2000 3. Liao GY, et al. Mol Pharma 59(5) :960-964, 2001. 4. Chang CG et al, Neurochem Res. 23(11):1371-7, 1998.

Additional Info

Recognizes human MDAR2B phosphorylated at serine 1303. Species crossreactivity: mouse and rat.

Alternative Names

N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, N-methyl-D-aspartate receptor subunit 3, hNR3, NR3