Supplier:
Alomone Labs Ltd.Cat no: N-170
NMDA
NMDA is the prototypic NMDA receptor agonist. An amino acid that, as a D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors.
NMDA is a water-soluble synthetic substance that is not normally found in biological tissues. It was first synthesized in the 1960s. NMDA is an excitotoxin in high quantities (it kills nerve cells by over-exciting them).
NMDA activates NMDA receptors by binding to NR2 subunits, leading to the opening of a non-specific cation channel, which can allow the passage of Ca2+ and Na+ ions into the cell and K+ ions out of the cell.
NMDA was evaluated for the inhibition of [3H]MK-801 binding at N-methyl-D-aspartate glutamate receptor and IC50 with an IC50 of 6.86 uM.
Cortical cultures of rat brain neurons have an estimated EC50 value of 6.8 micro M4. The EC50 found for NR2 subunit expressed in Xenopus oocytes was 21.7 uM.
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SPECIFICATIONS
Catalog Number
N-170
Size
50 mg
Concentration
6.5-500 uM
Shipping Temp
Room Temperature
Molecular Weight
147.1 Da
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