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NMDA Receptor NR1, Splice Variant N1 (N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1, NMDAR1, Nmdar, NR1, Glutamate [NMDA] Receptor Subunit zeta-1, Grin1, GluRdelta1, GluRzeta1, Glurz1, M100174, Rgsc174)

Cat no: N2904-31N

NMDA Receptor NR1, Splice Variant N1 (N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1, NMDAR1, Nmdar, NR1, Glutamate [NMDA] Receptor Subunit zeta-1, Grin1, GluRdelta1, GluRzeta1, Glurz1, M100174, Rgsc174)

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). NMDARs play an essential role in memory, neuronal development and have also been implicated in several disorders of the central nervous system including Alzheimer

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SPECIFICATIONS

Catalog Number

N2904-31N

Size

50ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Mouse, Rat

Form

Supplied as a lyophilized powder in 5mM ammonium bicarbonate. Reconstitute with 50ul phosphate buffered saline (PBS:137mM NaCl, 7.5mM Na2HPO4, 2.7mM KCl, 1.5mM KH2PO4, pH7.4) before use.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Grosshans DR, Clayton DA, Coultrap SJ, Browning MD. 2002. LTP leads to rapid surface expression on NMDA not AMPA receptors in adult rat CA1. Nature Neurosci. 5:27 - 33. 2. Luo JH, Wang YH, Yasuda RP, Dunah AW, Wolfe BB. 1997. The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Mol. Pharmacol. 51:79 - 86. 3. Zukin RS and Bennett MVL. 1995. Alternatively spliced isoforms of the NMDARI receptor subunit. Trends Neurosci., 18:306 - 313. 4. Laurie DJ. and Seeburg PH. 1994. Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J. Neurosci. 14:3180 - 3194. 5. Foldes RL, Rampersad V, Kamboj RK. 1994. Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits. Gene 147:303 - 304.

Additional Info

Recognizes mouse NMDA. Species crossreactivity: rat.

Alternative Names

Glutamate Receptor, Ionotropic, NMDA1 (zeta 1)

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info
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