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NMDAR1 (GRIN1, Glutamate [NMDA] Receptor Subunit zeta-1, N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1)

NMDAR1 (GRIN1, Glutamate [NMDA] Receptor Subunit zeta-1, N-methyl-D-aspartate Receptor Subunit NR1, NMD-R1)

Cat no: N2904-35F4

Supplier: United States Biological
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NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Western Blot: 2-4ug/ml, observed in rat brain lysates on ~110kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N2904-35F4
Reactivities: Human, Mouse, Rat, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Rajji T, Chapman D, Eichenbaum H, Greene R. The role of CA3 hippocampal NMDA receptors in paired associate learning. J Neurosci. 2006 Jan 18;26(3):908-15.
Additional info: Recognizes rat GRIN1. Species sequence homology: Canine, human and mouse.

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