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NMNAT1, Recombinant, Human (His) (Nicotinamide Mononucleotide Adenylyltransferase 1, NMN Adenylyltransferase 1, NaMN Adenylyltransferase 1)

NMNAT1, Recombinant, Human (His) (Nicotinamide Mononucleotide Adenylyltransferase 1, NMN Adenylyltransferase 1, NaMN Adenylyltransferase 1)

Cat no: 045090

Supplier: United States Biological
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NMNAT1 catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Interacts with ADPRT/PARP1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed with in brain, skeletal muscle, heart, liver, and kidney. Sequence: Human NMNAT1 (aa 2-279) is fused at the N-terminus to a His-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 045090
Size: 10ug
Form: Supplied as a liquid from a 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl.
Purity: >90% (SDS-PAGE)
Alternative names: Nicotinamide Mononucleotide Adenylyltransferase 1, NMN Adenylyltransferase 1, NaMN Adenylyltransferase 1
References: Product Reference: ?The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors: M. Watson, et al.; Mol. Cell. Biol. 29, 5872 (2009) ?

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