Norfloxacin, Hydrochloride (MK-366, Baccidal Barazan, Chibroxine)

Norfloxacin is a synthetic chemotherapeutic agent[1][2] occasionally used to treat common as well as complicated urinary tract infections.[3] It is sold under various brand names with the most common being Noroxin. In form of ophthalmic solutions it is known as Chibroxin. Norfloxacin is a second generation synthetic fluoroquinolone (quinolone) developed by Kyorin Seiyaku K.K. (Kyorin).[4]\n\nThe licensed uses for norfloxacin are quite limited as norfloxacin is to be considered a drug of last resort when all other antibiotics have failed. There are currently only three approved uses in the adult population[5] (one of which is restricted[6]) and the other ineffective due to bacterial resistance. Chibroxin[7] (ophthalmic) is approved for use in children older than one year of age.\nNorfloxacin interacts with a number of other drugs, as well as a number of herbal and natural supplements. Such interactions increase the risk of anticoagulation and the formation of non-absorbable complexes, as well as increasing the risk of toxicity.[8]\n\nNorfloxacin is associated with a number of serious and life threatening adverse reactions as well as spontaneous tendon ruptures and irreversible peripheral neuropathy. Such reactions may manifest long after therapy had been completed and in severe cases may result in life long disabilities. Hepatoxicity resulting in fatalities has also been reported with the use of norfloxacin.\n\nMelting Point: \n210-211 degrees C\n\nSolubility: \nDMSO, Methanol (sparingly)\n\nMethod for determining Identity:\nProton NMR Spectroscopic Analysis\n\nTLC Conditions:\nSiO2; Methanol: NH4OH; 9:1; Visualized with UV and AMCS; Single spot; Rf=0.3\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.\n\nToxicity and Hazards:\nDue to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.

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SPECIFICATIONS

Catalog Number

N4000-10

Size

10g

Form

Supplied as a light-yellow crystalline solid.

Purity

~90%

References

General References:\n1. Nelson, JM.; Chiller, TM.; Powers, JH.; Angulo, FJ. (Apr 2007). \"Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story.\". Clin Infect Dis 44 (7): 977

Alternative Names

MK-366, Baccidal Barazan, Chibroxine,