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NOS I (nNOS, bNOS, Nitric Oxide Synthase, NOS 1)

Cat no: N5350-03B

NOS I (nNOS, bNOS, Nitric Oxide Synthase, NOS 1)

Nitric oxide (NO), a diffusible free radical gas, affects a variety of physiological functions (1, 2). NO acts as a neurotransmitter in the brain and peripheral nervous systems. It accounts for the activity of endothelium-derived relaxing factors, which stimulate vasodilation by releasing NO from the endothelium. NO has been implicated in neurotoxicity associated with stroke and neuro-degenerative diseases, neuronal regulation of smooth muscle including peristalsis, and penile erections. In macrophages, NO mediates tumoricidal and bactericidal actions. It mediates the actions of the excitatory neurotransmitter glutamate in stimulation of cGMP levels. Unlike typical neurotransmitters, NO is not stored in synaptic vesicles and does not act on membrane receptors. Synthesis of NO, initially demonstrated in vascular endothelium, is now found in many tissues. NO is synthesized from L-arginine, oxygen, and NADPH by three known isoforms of heme-containing flavoproteins termed NO synthase (NOS I-III, M.W. ~130

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SPECIFICATIONS

Catalog Number

N5350-03B

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Rat

Form

Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.\n

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Recognizes rat nNOS.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info
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