Notch 2 Antibody

Cat no: 251992

Supplier: ABBIOTEC

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Description
Additional Information

Neurogenic locus notch homolog protein 2 (Notch 2) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), Notch 2 forms a transcriptional activator comple, Xenopus/Amphibian, with RBP-J kappa and activates genes of the enhancer of split locus. Notch 2 affects the implementation of differentiation,Porcineroliferation and apoptotic programs. Defects in Notch 2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

Catalogue number:	251992
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q04721
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Notch 2.
Format:	Each vial contains 0.1 mL of crude serum with 0.09% sodium azide.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Neurogenic locus notch homolog protein 2; Notch 2; hN2; NOTCH2