Notch3, CT (Notch homolog 3, Drosophila, hN3, CASIL, CADASIL)

Supplier:

United States Biological

Cat no: 031161

Notch3, CT (Notch homolog 3, Drosophila, hN3, CASIL, CADASIL)

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, ELISA.\n\nRecommended Dilution: \nELISA: 1:1,000\nWestern Blot: 1:100~1600\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

031161

Size

100ul

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, crude ascites with 0.09% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgG1

References

Liu, H., et al. Circ. Res. 107(7):860-870(2010)\nBailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)\nMenon, S., et al. Cephalalgia (2010) In press\nJugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)\nJohnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)

Additional Info

Human

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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