NOX4 (NADPH Oxidase 4, NOX-4, Renal NAD(P)H-Oxidase, RENOX, Kidney Superoxide-producing NADPH oxidase, KOX-1) (Biotin)

Supplier:

United States Biological

Cat no: N5376-77B

NOX4 (NADPH Oxidase 4, NOX-4, Renal NAD(P)H-Oxidase, RENOX, Kidney Superoxide-producing NADPH oxidase, KOX-1) (Biotin)

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested. \n\nRecommended Dilution: \nWestern Blot: 2ug/ml, recognizes a band at ~67 kD, representing isoform 1. \nimmunohistochemistry 5 ug/ml \nOptimal dilution determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

N5376-77B

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, NHP, Sheep

Conjugates

Biotin

Form

Supplied as a liquid in Tris-citrate-phosphate, pH 7-8, no preservativeadded.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.\n

Additional Info

Recognizes human NOX4. Species Homology: 100% human, mouse, rat, cow, sheep, and monkey proteins.

Alternative Names

EC=1.6.3

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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