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NR2E3 (Nuclear receptor subfamily 2, group E, Member 3, ESCS, MGC49976, Nuclear receptor subfamily 2 group E member 3, Photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37)

Cat no: N6889-94E

NR2E3 (Nuclear receptor subfamily 2, group E, Member 3, ESCS, MGC49976, Nuclear receptor subfamily 2 group E member 3, Photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37)

NR2E3 protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nWestern Blot: 2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nBovine Retina tissue lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

N6889-94E

Size

200ug

Applications

WB

Hosts

Rabbit

Reactivities

Bov

Form

Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinty chromatography

Isotype

IgG

Additional Info

Recognizes the bovine NR2E3 protein at ~44kD. Species Sequence Homology: mouse, rat and human

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