NR4A2, NT (Nuclear Receptor Subfamily 4 Group A Member 2, Orphan Nuclear Receptor NURR1, NURR1, TINUR, NURR1, Immediate-early Response Protein NOT, NOT, Transcriptionally Inducible Nuclear Receptor)

Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.\n\nApplications: \nSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-1:500\nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

N6889-95

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

P Type

Pab

Purity

Purified by ammonium sulfate precipitation.

Isotype

IgG

References

1.Perlmann T, et al. Cell Tissue Res. 318(1):45-52 (2004) 2.Hsu HC,et al. Curr Drug Targets Inflamm Allergy. 3(4):413-23 (2004) 3.Wallen-Mackenzie A, et al. Genes Dev. 17(24):3036-47 (2003) 4.Ichinose,H., et al. Gene 230(2), 233-239 (1999) 5.Okabe,T., et al. J. Immunol. 154(8), 3871-3879 (1995) 6.Mages,H.W., et al. Mol. Endocrinol. 8(11), 1583-1591 (1994).

Additional Info

Recognizes human NURR1.