NR5A1 (Steroidogenic factor 1, AD4BP, ELP, FTZ1, SF1, SF-1, STF-1, FTZF1, Adrenal 4-binding protein, Fushi tarazu factor homolog 1, Nuclear receptor subfamily 5 group A member 1, Steroid hormone receptor Ad4BP)

NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1), also known as SF1 or FTZ1, is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR5A1 gene. By linkage analysis using interspecific backcross mice, Swift and Ashworth (1995) mapped the Nr5a1 gene to mouse chromosome 2. Shen et al. (1994) proposed that SF1 regulates MIS in vivo and participates directly in the process of mammalian sex determination. SF-1 is a critical regulator of reproduction, regulating the transcription of key genes involved in sexual development and reproduction. Its targets include genes at every level of the hypothalamic-pituitary-gonadal axis, as well as many genes involved in gonadal and adrenal steroidogenesis.\n\nUniProt Number:\nQ13285\n\nGene ID:\nNR5A1\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry (Paraffin).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

145234

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Jameson JL (2004). \"Of mice and men: The tale of steroidogenic factor-1.\". J. Clin. Endocrinol. Metab. 89 (12): 5927

Additional Info

Recognizes human,mouse and rat NR5A1. No crossreactivity with other proteins.