NRXN3, CT (NRXN3, KIAA0743, Neurexin-3-beta, Neurexin III-beta, Neurexin-3-beta, soluble form, Neurexin-3-beta, C-terminal fragment) (AP)

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

039158-AP

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Alkaline Phosphatase.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)\nHotta, K., et al. J. Hum. Genet. (2010) In press :\nRose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :\nCirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)\nNovak, G., et al. World J. Biol. Psychiatry 10 (4 PT 3), 929-935 (2009) :

Additional Info

Human

Alternative Names

NRXN3, KIAA0743, Neurexin-3-beta, Neurexin III-beta, Neurexin-3-beta, soluble form, Neurexin-3-beta, C-terminal fragment