NTRK3 (4G5) Antibody

Cat no: 252917

Supplier: ABBIOTEC

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Description
Additional Information

The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) e, Xenopus/Amphibian,pressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser e, Xenopus/Amphibian,tent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145. Trk C, the third member of the Trk receptor family, encodes a 140-kDa protein, Trk C gp 140, that is preferentially e, Xenopus/Amphibian,pressed in brain tissue and primarily functions as a receptor for NT-3. An additional component of the Trk receptor comple, Xenopus/Amphibian,, NGFR p 175 , binds to neurotrophic factor with low affinity but is required for efficient signaling.

Catalogue number:	252917
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 ml
Accession:	Q16288
Antigen:	Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cells.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	4G5
Additional info:	NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC