Nucleophosmin (7H10) Antibody

Cat no: 252594

Supplier: ABBIOTEC

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Description
Additional Information

Nucleophosmin (NPM) is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities . The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.

Catalogue number:	252594
Reactivities:	Human, Mouse
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	P06748
Antigen:	Purified recombinant fragment of human NPM e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	7H10B9
Additional info:	Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Numatrin; Nucleolar protein NO38; NPM1; NPM