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NUMB (Protein Numb Homolog, h-Numb, Protein S171)

NUMB (Protein Numb Homolog, h-Numb, Protein S171)

Cat no: N8350-01G

Supplier: United States Biological
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Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Applications: Suitable for use in ELISA, Immunocytochemistry, Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.03-0.1ug/ml, mouse brain lysates observed on ~80kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: N8350-01G
Reactivities: Human, Mouse, Bovine, Canine
Hosts: Goat
Applications: ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Ma Q, Zhou L, Shi H, Huo K. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Cell Signal. 2008 Jun;20(6):1044-51. 2. Corallini S, Fera S, Grisanti L, Falciatori I, Muciaccia B, Stefanini M, Vicini E. Expression of the adaptor protein m-Numb in mouse male germ cells. Reproduction. 2006 Dec;132(6):887-97. 3. Di Marcotullio L, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M, Screpanti I, Gulino A. Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol. 2006 Dec;8(12):1415-23. 4. Holowacz T, Zeng L, Lassar AB. Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Dev Dyn. 2006 Mar;235(3):633-45. 5. Zigman M, Cayouette M, Charalambous C, Schleiffer A, Hoeller O, Dunican D, McCudden CR, Firnberg N, Barres BA, Siderovski DP, Knoblich JA. Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron. 2005 Nov 23;48(4):539-45. 6. Fassa A, Mehta P, Efthimiopoulos S. Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner. J Neurosci Res. 2005 Oct 15;82(2):214-24. 7. Sanada K, Tsai LH. G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell. 2005 Jul 15;122(1):119-31.
Additional info: Recognizes mouse NUMB. Species sequence homology: Bovine, canine and human.

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