O-glycosylation typically occurs in secreted proteins and membrane-bound proteins, taking place within the Golgi apparatus. O-glycans are linked to proteins through serine and threonine, and then to hydroxyproline and hydroxylysine. The primary method of O-glycosylation for secreted and membrane proteins involves reducing N-acetylgalactosamine (GalNAc) at the reducing end. O-glycans are considered "mucin-type" glycans. In addition to mucin-type O-linked glycans, many mammalian proteins also connect through
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