OATP1, Control Peptide, Rat (Organic Anion Transporting Polypeptide 1)

Supplier:

United States Biological

Cat no: O3000-05

OATP1, Control Peptide, Rat (Organic Anion Transporting Polypeptide 1)

Control Peptide for O3000-06 (antiserum) and O3000-04 (affinity purified)\n\nAn 17aa Peptide internal sequence (middle regions) of rat oatp1 \n \nMammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus).\n\nRat Oatp, now called oatp1, encodes a protein of 670 aa. Oatp1 was localized at the apical portions of the S3 segment of the proximal tubule, and at the apical surface of the choroid plexus of rat brain. It is also found in liver, lung, skeletal muscle, and colon. It mediates Na+-independent uptake of wide range of amphipathic substrates including sulfobromopthalein (BSP), bile acids, estrogen conjugates, and neutral steroids, etc. Human liver OATP (670 aa) is only 67% homologous with rat oatp1. It differs in functional properties from rat oatp1 and highly expressed in brain.\n\nApplications:\nSuitable for use in ELISA and Antibody Blocking. Other applications not tested.\n\nRecommended Dilutions:\nELISA: 50-100ng/well. Not suitable for Western Blot due to low MW <3kD. \nAntibody Blocking: 5-10ug for 1ug O3000-04 affinity purified or 1ul O3000-06 serum.\nOptimal dilution determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

O3000-05

Size

50ug

Applications

ELISA, WB

Reactivities

Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide

Purity

Highly purified

References

1. Jacquemin E et al (1994) PNAS 91, 133-137; 2. Kullak-Ublick, GA et al (1995) gastroenterol. 109, 1274-1282

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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