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OCT4 (1D10) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252840

OCT4 (1D10) Antibody

Oct4 (Octamer-binding transcription factor-4) and Oct-3/4, also known as POU5F1 (POU class 5 homeobo, Xenopus/Amphibian, 1), octamerbinding transcription factor-3 (Oct-3, Otf-3),Mouse,odulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3/4 sustains stem-cell self renewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene e, Xenopus/Amphibian,pression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.

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SPECIFICATIONS

Catalog Number

252840

Size

0.1 ml

Applications

WB

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of Oct4(aa193-360) e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

Q01860

Clonality

1D10H6

Additional Info

POU domain, class 5, transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3; OCT3; OCT4; OTF3; POU5F1

SUPPLIER INFO

ABBIOTEC

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