OCT4 (7E7) Antibody

Cat no: 253078

Supplier: ABBIOTEC

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Description
Additional Information

Oct4 (Octamer-binding transcription factor-4) and Oct-3/4, also known as POU5F1 (POU class 5 homeobo, Xenopus/Amphibian, 1), octamerbinding transcription factor-3 (Oct-3, Otf-3),Mouse,odulates embryonic stem (ES) cell populations by influencing lineage commitment. Oct-3/4 sustains stem-cell self renewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene e, Xenopus/Amphibian,pression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.

Catalogue number:	253078
Reactivities:	Human
Applications:	Immunofluorescence
Size:	0.1 ml
Accession:	Q01860
Antigen:	Synthesized peptide derived from internal of human POU5F1.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	7E7
Additional info:	POU domain, class 5, transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3; OCT3; OCT4; OTF3; POU5F1