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OGT (UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110kD Subunit, O-linked N-acetylglucosamine Transferase 110kD Subunit, O-GlcNAc Transferase Subunit p110)

OGT (UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110kD Subunit, O-linked N-acetylglucosamine Transferase 110kD Subunit, O-GlcNAc Transferase Subunit p110)

Cat no: O5750-01C

Supplier: United States Biological
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O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 0.05-0.2ug/ml, observed in pancreas lysates from rat and mouse on ~110kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: O5750-01C
Reactivities: Human, Mouse, Rat, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Majumdar G, Wright J, Markowitz P, Martinez-Hernandez A, Raghow R, Solomon SS. Insulin stimulates and diabetes inhibits O-linked N-acetylglucosamine transferase and O-glycosylation of Sp1. Diabetes. 2004 Dec;53(12):3184-92.
Additional info: Recognizes OGT. Species Crossreactivity: Mouse and rat. Species sequence homology: Canine and human.

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