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Okadaic Acid (sodium salt)

Cat no: O-900

Okadaic Acid (sodium salt)

Okadaic Acid, Sodium salt, Sodium Salt (#O-900), PP-2A, Protein Phosphatases. Okadaic acid is a polyether compound, isolated from a black sponge, Halichondria okadai. It is previously demonstrated as a non-TPA-type tumor promoter and then as a cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 and 2A. In higher concentrations Okadaic acid induced apoptosis (IC50 = 0.5 μM).

Okadaic acid down-regulated the TNF receptor, induces the release of Ca2+ from intracellular stores in ECV304 endothelial cells and inhibits GH4 cell proliferation in a concentration-dependent manner (IC50 = 5 nM). Cell Signaling Activators and Inhibitors, Apoptosis Inducers. Protein Phosphatase Inhibitors; Protein Phosphatase Inhibitors (PP-1 and PP-2A).

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SPECIFICATIONS

Catalog Number

O-900

Size

5 x 25 micro g

Purity

>98%

Concentration

50-100 nM

Shipping Temp

Room Temperature

Molecular Weight

827

SUPPLIER INFO

Alomone Labs Ltd.

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