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Olomoucine

Cat no: O-300

Olomoucine

Olomoucine. A Cyclin Dependent Kinase (CDK) Inhibitor.

OlomoucineпїЅis a cell-permeable purine protein kinase inhibitor, found to be highlyпїЅspecific for the cell-cycleпїЅregulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases,пїЅthe brain p33cdk5/p35 kinase and the ERK1/2 MAP- kinase (IC50=7-25 uM).
OlomoucineпїЅbehaves as a competitive inhibitor for ATP and as a non-competitiveпїЅinhibitor for histone H1 binding in CDKs kinases.
Olomoucine induces a dose-dependent inhibitionпїЅof proliferation rateпїЅand the cell cycle progression in many human cancer cells in culture (EC50=40-90uM). Olomoucine, at 1-100 uM, slowdown or arrest KB 3-1 cells in G1/S and G2/M phase and decreased the DNA synthesis of rat brain cortex.
Olomoucine also induces apoptosis in maturing cerebellar granule neurons,пїЅNGF induced neuronal differentiationпїЅof PC12 cellsпїЅinпїЅvitroпїЅand in NE cellsпїЅinпїЅvivo.

Protein Kinase Inhibitors and Activators; CDK Inhibitors

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SPECIFICATIONS

Catalog Number

O-300

Size

1 mg

Purity

>99%

Concentration

20 - 200 micro M

Shipping Temp

Room Temperature

Molecular Weight

298.35

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