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omega-Conotoxin MVIIC

Cat no: C-150

omega-Conotoxin MVIIC

omega-Conotoxin MVIIC. A Blocker of Presynaptic Cav (N-type and P/Q type) Channels. omega-Conotoxin MVIIC, blocks CaV2.1 (alpha1A, P/Q-type) and Cav2.2 (alpha1B, N-type) channels. The toxin binds with high affinity to Cav2.1 and with lower affinity to Cav2.2 in rabbit brain. However, the block by omega-Conotoxin-MVIIC, of N-type channels in DRG neurons developed much faster than the block of P-type currents in Purkinje cells. The effect of the toxin is modulated by voltage (i.e. it is more potent for inactivated channels). In addition this toxin was reported to block nicotinic receptors (transiently expressed in Xenopus oocytes) with IC50 of 1.3 mM. It was also shown to inhibit K+-induced H-GABA release in hippocampus in vivo. This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations.
Ion Channel Modulators> Voltage - Gated Ca2+пїЅChannel Blockers.

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SPECIFICATIONS

Catalog Number

C-150

Size

0.1 mg

Purity

>99%

Concentration

50 nM - 1 micro M

Shipping Temp

Room Temperature

Molecular Weight

2750 da

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