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p-Adducin (alpha) (T445) pAb

p-Adducin (alpha) (T445) pAb

Cat no: BS4258

Supplier: Bioworld Technology, Inc.
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Adducins are a family of cytoskeleton proteins encoded by three genes ((alpha), (beta), (gamma)). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin (alpha) is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin (alpha) and Adducin (gamma) is ubiquitous in contrast to the restricted expression of Adducin (beta). Adducin (beta) is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.
Catalogue number: BS4258
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P35611
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Adducin (alpha) around the phosphorylation site of Threonine 445.
Species: p-Adducin (alpha) (T445) pAb detects endogenous levels of Adducin (alpha) protein only when phosphorylated at Thr445.
Molecular weight: ~ 81 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Alpha-adducin; Erythrocyte adducin subunit alpha; ADD1; ADDA; (alpha)-Adducin; Adducin1; Adducin-1; (alpha) Adducin;
Additional info: For research use only, not for use in diagnostic procedure.

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