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p-EGFR (Y1148) Peptide

p-EGFR (Y1148) Peptide

Cat no: BS5011P

Supplier: Bioworld Technology, Inc.
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EGFR (Epidermal growth factor receptor, ErbB-1) is a receptor tyrosine kinase (RTK) that is one of four members of the EGFR/ErbB family of receptor tyrosine kinases. EGFR plays a key role in the regulation of essential normal cellular processes and in the pathophysiology of hyperproliferative diseases such as cancer. Activation of the EGFR signaling pathway has been linked with increased cell proliferation, angiogenesis, metastasis and decreased apoptosis.The GRB2 adaptor protein binds activated EGFR at phospho-Tyr1068. A pair of phosphorylated EGFR residues (Tyr1148 and Tyr1173) provide a docking site for the Shc scaffold protein, with both sites involved in MAP kinase signaling activation.
Catalogue number: BS5011P
Applications: Block/Neutralize/Inhibit
Swiss prot: P00533
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-EGFR (Y1148). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Epidermal growth factor receptor; EC=2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1; EGFR
Additional info: This peptide can be used with studies using BS5011 p-EGFR (Y1148) pAb.

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