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p-IkB-(beta) (T19) pAb

p-IkB-(beta) (T19) pAb

Cat no: BS4576

Supplier: Bioworld Technology, Inc.
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The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK(alpha) and IKK(beta) serve as the catalytic subunits of the kinase and IKK(gamma) serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK(beta) (Ser176 and Ser180 in IKK(alpha)), which causes conformational changes, resulting in kinase activation.
Catalogue number: BS4576
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q15653
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human IkB-(beta) around the phosphorylation site of Threonine 19.
Species: p-IkB-(beta) (T19) pAb detects endogenous levels of IkB-(beta) protein only when phosphorylated at Thr19.
Molecular weight: ~ 48 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: I kappa B beta; IKB B; IKB beta; IKBB; IkBbeta; IkappaBbeta; NF kappa B inhibitor beta; NF kappa BIB; NFKBIB; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta; TR interacting protein 9; TRIP 9; TRIP9; Thyroid receptor
Additional info: For research use only, not for use in diagnostic procedure.

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