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p-PLC gamma 1 (Y1253) Peptide

p-PLC gamma 1 (Y1253) Peptide

Cat no: BS4865P

Supplier: Bioworld Technology, Inc.
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Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma 1, PLC gamma 2, PLC delta1, PLC delta2 and PLC E. PLC gamma 1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC gamma 1 in the brush border of intestinal epithelial cells. Villin regulates PLC gamma 1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC gamma 1 binds alpha1beta1 Integrin and modulates alpha1beta1 Integrin-specific adhesion. PLC gamma 1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells.
Catalogue number: BS4865P
Applications: Block/Neutralize/Inhibit
Swiss prot: P19174
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-PLC gamma 1 (Y1253). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C2; PLC2I; Phospholipase C-gamma-1; PLC-gamma-1; PLCG1; PLC1; PLCgamma 1;
Additional info: This peptide can be used with studies using BS4865 p-PLC gamma 1 (Y1253) pAb.

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