p-SHP-1 (Y536) Peptide

Cat no: BS4169P

Supplier: Bioworld Technology, Inc.

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Additional Information

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

Catalogue number:	BS4169P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P29350
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-SHP-1 (Y536). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	PTPN6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1; SH-PTP1;
Additional info:	This peptide can be used with studies using BS4169 p-SHP-1 (Y536) pAb.

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p-SHP-1 (Y536) Peptide

Cat no: BS4169P

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