Paclitaxel (Taxol, BMS 181339-01, NSC 125973)

Anticancer compound. \nChemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. \nMicrotubule assembly stabilizer. Reversibly binds to polymerized tubulin. \nAnti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase.\n Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK).\n Immunosuppressor. Immunostimulant. \nAntiproliferative agent for the prevention of restenosis.\n\n\nStorage and Stability:\nShort-term Storage: +4 degrees C\nLong-term Storage: -20 degrees C\nStable for at least 2 years after receipt when stored at -20 degrees C.

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SPECIFICATIONS

Catalog Number

045125

Size

1mg

Purity

>99% (HPLC)

References

Product Reference: \n?Cytotoxic studies of paclitaxel (Taxol(R)) in human tumour cell lines: J.E. Liebmann, et al.; Br. J. Cancer 68, 1104 (1993)\n?Taxol (paclitaxel): mechanisms of action: S.B. Horwitz; Ann. Oncol. 5, S3 (1994) (Review)\n?Taxol (paclitaxel): a novel anti-microtubule agent with remarkable anti-neoplastic activity: R. Foa, et al.; Int. J. Clin. Lab. Res. 24, 6 (1994) (Review)\n?Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway: C.M. Woods, et al.; Mol. Med. 1, 506 (1995)\n?Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998)\n?How Taxol stabilises microtubule structure: L.A. Amos & J. L

Alternative Names

Taxol, BMS 181339-01, NSC 125973