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Paclitaxel (Taxol, BMS 181339-01, NSC 125973)

Cat no: 045125


Supplier: United States Biological
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Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle arrest at the G2/M phase. Apoptosis inducer through aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK). Immunosuppressor. Immunostimulant. Antiproliferative agent for the prevention of restenosis. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C.
Catalogue number: 045125
Size: 1mg
Purity: >99% (HPLC)
Alternative names: Taxol, BMS 181339-01, NSC 125973
References: Product Reference: ?Cytotoxic studies of paclitaxel (Taxol(R)) in human tumour cell lines: J.E. Liebmann, et al.; Br. J. Cancer 68, 1104 (1993) ?Taxol (paclitaxel): mechanisms of action: S.B. Horwitz; Ann. Oncol. 5, S3 (1994) (Review) ?Taxol (paclitaxel): a novel anti-microtubule agent with remarkable anti-neoplastic activity: R. Foa, et al.; Int. J. Clin. Lab. Res. 24, 6 (1994) (Review) ?Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway: C.M. Woods, et al.; Mol. Med. 1, 506 (1995) ?Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) ?How Taxol stabilises microtubule structure: L.A. Amos & J. L

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