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Products Paclitaxel (Taxol)
| Catalogue number: | P1792A |
| Size: | 100mg |
| Form: | As reported |
| Purity: | HPLC: ~99% TLC: ~99% |
| References: | 1. Wani, M.C., et al. "Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia." J. Am. Chem. Soc. 93:2325-2327 (1971). 2. McGuire, W.P., et al. "Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms" Ann. Int. Med. 111:273-279 (1989). 3. Rowinsky, E.K., et al. "Taxol: a novel investigational antimicrotubule agent." J. Natl. Cancer Inst. 82:1247-1259 (1990). 4. Parekh, H. and Simpkins, H. "The transport and binding of taxol." Gen. Pharmacol. 29:167-172 (1997). 5. Jordan, A., et al. "Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle investigational antimicrotubule agent." Med. Res. Rev. 18:259-296 (1998). 6. Wang, T.H., et al. "Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells." J. Biol. Chem. 274:8208-8216 (1999). 7. Shtil, A.A., et al. "Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells." Oncogene 18:377-384 (1999). 8. Srivastava, R.K., et al. "Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase." Mol. Cell. Biol. 18:3509-3517 (1998). 9. Torres, K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell death are concentration dependent." Cancer Res. 58:3620-3626 (1998). |
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