Paclitaxel (Taxol)

Supplier:

United States Biological

Cat no: P1792A

Paclitaxel (Taxol)

Antitumor and antileukemic agent isolated from the bark of the yew tree, Taxus brevifolia.\n\nSolubility:\nSoluble in DMSO at 200mg/ml; soluble in ethanol at 40mg/ml; very poorly soluble in water; maximum solubility in water is ~10-20uM; buffers, serum or other additives may increase or decrease the aqueous solubility.\n\nMelting Point: \nAs reported\n\nElemental Analysis:\nCalculated:\nC: 64.74%\nH: 6.13%\nN: 1.61%\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P1792A

Size

100mg

Form

As reported

Purity

HPLC: ~99%\nTLC: ~99%

References

1. Wani, M.C., et al. \"Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.\" J. Am. Chem. Soc. 93:2325-2327 (1971). 2. McGuire, W.P., et al. \"Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms\" Ann. Int. Med. 111:273-279 (1989). 3. Rowinsky, E.K., et al. \"Taxol: a novel investigational antimicrotubule agent.\" J. Natl. Cancer Inst. 82:1247-1259 (1990). 4. Parekh, H. and Simpkins, H. \"The transport and binding of taxol.\" Gen. Pharmacol. 29:167-172 (1997). 5. Jordan, A., et al. \"Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle investigational antimicrotubule agent.\" Med. Res. Rev. 18:259-296 (1998). 6. Wang, T.H., et al. \"Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells.\" J. Biol. Chem. 274:8208-8216 (1999). 7. Shtil, A.A., et al. \"Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.\" Oncogene 18:377-384 (1999). 8. Srivastava, R.K., et al. \"Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase.\" Mol. Cell. Biol. 18:3509-3517 (1998). 9. Torres, K., and Horwitz, S.B. \"Mechanisms of Taxol-induced cell death are concentration dependent.\" Cancer Res. 58:3620-3626 (1998).

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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