Paired Immunoglobulin-Like Type 2 Receptor alpha, Recombinant, Mouse (PILR-alpha, PILRa)

PILR-alpha (paired immunoglobulin-like type 2 receptor-alpha; also FDF03) is one of two members of a small family of immunoregulatory Ig-superfamily receptors (1, 2). It is a counterpart to PILR-Beta and it likely gave rise to PILR-Beta through gene duplication and rearrangement (1). The PILRs represent one of many pairs of Ig-like domain-containing receptors that participate in immune regulation. PILR-alpha and -Beta should not be confused with the similarly named PIRs (also paired immunoglobulin-like receptors ), or the functionally-related SIRP and ILT/LILR/CD85/LIR family of receptors (2). While PIRs, ILTs and SIRPs contain three to six Ig-like domains in their extracellular region, PILR-alpha and -Beta show only one Ig-like region in their extracellular domain (ECD) (1, 2). Mouse PILR-alpha is a monomeric, 271 amino acid (aa) type I transmembrane (TM) protein (3). It contains a 167 aa ECD, a 21 aa TM segment, and a long, 83 aa cytoplasmic region. The ECD shows one V-type Ig-like domain between aa 39-157, while the cytoplasmic region contains two ITIMs (immunoreceptor Tyr-based inhibitory motifs) between aa

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

P2150-48

Size

50ug

Applications

WB

Reactivities

Mouse

Form

Supplied as a lyophilized powder in PBS. Reconstitute with sterile PBS to (same/more than) 0.1mg/ml.

Purity

(same/more than) 95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin (same/less than) 1EU.

References

1. Wilson, M.D. et al. (2006) Physiol. Genomics 27:201.\n2. Lanier, L.L. (2001) Curr. Opin. Immunol. 13:326.\n3. Fournier, N. et al. (2000) J. Immunol. 165:1197.\n4. Shiratori, I. et al. (2004) J. Exp. Med. 199:525.\n5. SwissProt # Q2YFS3.