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MtoZ Biolabs

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PALB2 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 251230

PALB2 Antibody

Partner and localizer of BRCA2 (PALB2) plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. PALB2 serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 comple, Xenopus/Amphibian, which is essential for homologous recombination. PALB2 strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Defects in PALB2 are the cause of Fanconi anemia complementation group N (FANCN). FANCN is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.

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SPECIFICATIONS

Catalog Number

251230

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PALB2.

Isotype

Rabbit Ig

Accession

Q86YC2

Additional Info

PALB2; Partner and localizer of BRCA2; FANCN

SUPPLIER INFO

ABBIOTEC

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