PALB2 Antibody

Cat no: 251230

Supplier: ABBIOTEC

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Description
Additional Information

Partner and localizer of BRCA2 (PALB2) plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. PALB2 serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 comple, Xenopus/Amphibian, which is essential for homologous recombination. PALB2 strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Defects in PALB2 are the cause of Fanconi anemia complementation group N (FANCN). FANCN is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.

Catalogue number:	251230
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q86YC2
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PALB2.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	PALB2; Partner and localizer of BRCA2; FANCN