Pan-Cadherin Antibody

Cat no: 251786

Supplier: ABBIOTEC

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Description
Additional Information

Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins.

Catalogue number:	251786
Reactivities:	Human, Mouse, Chicken/Bird, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P10288
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of chicken pan-cadherin.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	PC-79
Additional info:	Pan-Cadherin; Cadherin; CDH; Cadherin-2; DH2; Neural cadherin; N-cadherin