Specific for human PAPP-A antigen purified from placental blood (heterotetrameric complex, consisting of PAPP-A subunits and proMBP subunits). MAbs 11E4 and 5H9 are specific to proMBP subunit.htPAPP-A and dPAPP-A (PAPP-A dimer) immunoassays and immunoprecipitation. Recommended pairs for the detection of dPAPP-A antigen in blood of AMI patients and patients with unstable angina (capture - detection): 4G11 - 3C8 4G11 - 10H9 10E1 - 7A6 Best pairs for the detection of htPAPP-A antigen in pregnancy serum (capture - detection): 4G11 - 3C8 4G11 - 10H9 10E2 - 10E1 10E2 - 5H9 5H9 - 10E2 10E1 - 7A6. PAPP-A immunodetection in Western blotting. MAb 18A10 recognizes PAPP-A subunit in reducing and non-reducing conditions after antigen transfer onto nitrocellulose membrane after SDS-gel electrophoresis. MAbs 4G11, 10A5, 18A10 and 10E1 recognize htPAPP-A, consisting of PAPP-A subunits and proMBP subunits, in non-reducing conditions.
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