PAPPA, Recombinant, Human, Western Blot Control (Pappalysin-1, Insulin-like Growth Factor-dependent IGF-binding Protein 4 Protease, IGF-dependent IGFBP-4 Protease, IGFBP-4ase, Pregnancy-associated Plasma Protein A, PAPP-A)

Supplier:

United States Biological

Cat no: P6000-83A

PAPPA, Recombinant, Human, Western Blot Control (Pappalysin-1, Insulin-like Growth Factor-dependent IGF-binding Protein 4 Protease, IGF-dependent IGFBP-4 Protease, IGFBP-4ase, Pregnancy-associated Plasma Protein A, PAPP-A)

PAPP-A is a large zinc binding protein, which acts as a metalloprotease and has been shown to cleave insulin-like growth factor binding protein-4. PAPP-A can act as a regulator of IGF bioactivity in several biological systems, including the human ovary and cardiovascular systems. Recent studies have shown that levels are elevated in patients with unstable angina or acute myocardial infarction. PAPP-A is also produced in high concentrations during pregnancy and is released into the maternal circulation. Low levels of PAPP-A have been linked with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth.\n\nSource: \nRecombinant corresponding to aa81-271 from

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SPECIFICATIONS

Catalog Number

P6000-83A

Size

10ug

Applications

WB

Form

Supplied as a liquid in 25mM Tris-HCl, pH6.8, 50mM DTT, 1% SDS, 0.1% Bromophenol Blue, 2.5% glycerol.

Purity

Purified (SDS-PAGE).

References

1. Conover, C.A. et al., 2004 Development 131 (5) 1187-1194.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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