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Paraherquamide E (Antibiotic VM 54159, 14-Deoxy-paraherquamide A)

Cat no: P3106-82

Paraherquamide E (Antibiotic VM 54159, 14-Deoxy-paraherquamide A)

Paraherquamide E is a member of the paraherquamide family which cause a potent non-toxic paralysis of nematodes and has led to the investigation of their potential as anthelmintics. Although paraherquamide A has received more attention, paraherquamide E has been shown to be the more potent anthelmintic in vivo. Paraherquamide E was found to be the most potent insecticide in a series of paraherquamide analogues against a hemipteran with an LD50 of 0.089 ug/nymph. \n\nSoluble in ethanol, methanol, DMF or DMSO

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SPECIFICATIONS

Catalog Number

P3106-82

Size

500ug

Form

White solid

Purity

>99% by HPLC

References

1. Insecticidal activity of paraherquamides, including paraherquamide H and paraherquamide I, two new alkaloids isolated from Penicillium cluniae. Lopez-Gresa M.P. et al. J. Agric. Food Chem. 2006, 54, 2921. 2. Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle. Robertson A.P. et al. J. Pharmacol. Exp. Ther. 2002, 302, 853. 3. New paraherquamide antibiotics with anthelmintic activity. Blanchflower S.E. et al. J. Antibiot. 1991, 44, 492. 4. Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity. Ondeyka J.G. J. Antibiot. 1990, 43, 1380.

Alternative Names

Antibiotic VM 54159, 14-Deoxy-paraherquamide A

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