Home  >  Products  >  PARD6A (Partitioning Defective 6 Homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax Interaction Protein 40, TIP-40, PAR6A)
PARD6A (Partitioning Defective 6 Homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax Interaction Protein 40, TIP-40, PAR6A)

PARD6A (Partitioning Defective 6 Homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax Interaction Protein 40, TIP-40, PAR6A)

Cat no: P3105-89F

Supplier: United States Biological
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PAR6 is a cell membrane protein involved in cell polarization and asymmetrical cell division processes as part of a multi protein complex. It is thought to be involved in the invasive phenotype that is associated with metastatic carcinomas, playing a role in the epithelial to mesenchymal transition (EMT). PAR6 is also thought to be involved in the formation of epithelial tight junctions. PAR6 contains a semi Cdc42/Rac interactive binding (CRIB) domain and a PDZ (PSD95/Discs-large/ZO1) domain, and several different PAR6 isoforms have been identified. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Immunohistochemistry (Paraffin): 5-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P3105-89F
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Johansson A, Driessens M, Aspenstrom P. The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J Cell Sci. 2000 Sep;113(Pt18):3267-75.
Additional info: Recognizes human PARD6A.

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