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PAX5 (Paired Box Protein Pax-5, B-cell-specific Transcription Factor, BSAP, PAX-5)

PAX5 (Paired Box Protein Pax-5, B-cell-specific Transcription Factor, BSAP, PAX-5)

Cat no: P3113-83V1

Supplier: United States Biological
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Pax-5 is a 46kD, B cell specificactivator protein (BSAP). In the early stages of B cell developmemt, Pax-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. Pax-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Interestingly, Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. This indicates that Pax-5 is important in B cell development, but may also have a role in proper neuronal development. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 0.3-1ug/ml, human lymph and human spleen lysates observed on ~40kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: P3113-83V1
Reactivities: Human, Mouse
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Adams B, Dorfler P, Aguzzi A, Kozmik Z, Urbanek P, Maurer-Fogy I, Busslinger M. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev 1992 Sep;6(9):1589-607.
Additional info: Recognizes human PAX5. Species sequence homology: Mouse.

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