Pax6, Control Peptide (Paired Box Gene 6, AN2, D11S812E, MGDA, WAGR)

Supplier:

United States Biological

Cat no: P3113-84C

Pax6, Control Peptide (Paired Box Gene 6, AN2, D11S812E, MGDA, WAGR)

Retinal progenitor cells (RPCs) retain the ability to generate different retinal cell types. RPCs appear to be retained in a progenitor state by the action of Notch-Delta signaling and downstream effectors of Notch, like the bHLH transcription factor Hes1. The most uncommitted RPCs (retinal stem cells) in the ciliary margin of the Xenopus retina were shown to coexpress\nthe transcription factors Pax6, RX1, and Six3 prior to the activation of neurogenic genes (Notch, Delta, bHLH) and the subsequent steps toward retinal neurogenesis. Pax6 is required for the multipotent state of retinal progenitor C. Upon Pax 6 inactivation, the potential of RPCs becomes entirely restricted to only one of the cell fates normally available to RPCs resulting in the exclusive generation of amacrine interneurons. Pax6 has been found to directly control the transcriptional activation of retinogenic bHLH factors that bias subsets of RPCs towards different retinal cell fates, thereby mediating the full retinogenic potential of RPCs.\n\nApplications: \nSuitable for use in Antibody blocking (AB5409). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

P3113-84C

Size

100ug

Form

Supplied as a liquid.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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