PAX6 (PAX6, AN2, Paired box protein Pax-6, Aniridia type II protein, Oculorhombin)

Supplier:

United States Biological

Cat no: 030530

PAX6 (PAX6, AN2, Paired box protein Pax-6, Aniridia type II protein, Oculorhombin)

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells .PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.\n\nApplications:\nWestern Bloting: 1:500-1:2000.\nFlow cytometry: 1:200-1:400.\nELISA: Suggested dilution 1:10000.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

030530

Size

100ul

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

Form

Ascites fluid, 0.03% sodium azide.

P Type

Mab

Purity

Ascites

Isotype

IgG1

References

1.Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2581-90.\n2.J Biol Chem. 2009 Oct 2;284(40):27524-32. \n3.J Biol Chem. 2010 Jan 22;285(4):2527-36.

Additional Info

Human

Alternative Names

AN; AN2; MGDA; WAGR; D11S812E; MGC17209; PAX6

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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