Pazopanib, Free Base (5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamid, Armala, GW-786034)

Supplier:

United States Biological

Cat no: P3113-97A

Pazopanib, Free Base (5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamid, Armala, GW-786034)

Pazopanib is an oral, second-generation, potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor and c-kit, key proteins responsible for tumor growth and angiogenesis. Pazopanib showed good potency against all of the human VEGFRs and some related tyrosine receptor kinases in vitro, and demonstrated antitumor activity against renal cell carcinoma (RCC), and breast, lung, and other related cancers.\n\nSolubility:\nSoluble in DMSO at 8.3mg/ml with slight warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.\n\nMelting Point:\n309-311 C\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P3113-97A

Size

25mg

Form

Supplied as a white to off-white powder.

Purity

~99%

References

1. Sloan, B. and Scheinfeld, N.S. \"Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy.\" Curr. Opin. Investig. Drugs 9:1324-1335 (2008). 2. Sonpavde, G., et al. \"Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma.\" Expert Opin. Investig. Drugs 17:253-261 (2008). 3. Takahashi, K., et al. \"Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib.\" Arch. Ophthalmol. 127:494-499 (2009). 4. Podar, K., et al. \"The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma.\" Proc. Natl. Acad. Sci. USA 103:19478-19483 (2006).

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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