PCSK2, Recombinant, Human (Neuroendocrine Convertase 2, NEC 2, KEX2-like Endoprotease 2, Prohormone Convertase 2, Proprotein Convertase 2, PC2, NEC2)

Supplier:

United States Biological

Cat no: P9052-11C

PCSK2, Recombinant, Human (Neuroendocrine Convertase 2, NEC 2, KEX2-like Endoprotease 2, Prohormone Convertase 2, Proprotein Convertase 2, PC2, NEC2)

Proprotein Convertase 2 (PCSK2) is a subtilisin-like serine peptidase that processes proteins into biologically active products in the secretory pathway. Like other furin/kexin family members, PCSK2 cleaves its substrates primarily after sites of paired basicaaresidues. Autoactivation of PCSK2 occurs in a post-Golgi compartment of the secretory system. Interaction with the secretory protein 7B2 is required for proper activation of PCSK2. The N-terminal domain of 7B2 stabilizes active PCSK2, and a C-terminal fragment of 7B2 can inhibit PCSK2 activity. rhPCSK2 was coexpressed with 7B2 to facilitate activation of the enzyme. PCSK2 is a major proteolytic processing enzyme of the regulated secretory pathway of the neuroendocrine system, where it generates a number of hormones and neuropeptides. Products of PCSK2 processing include enkephalins, insulin, somatostatin, dynorphin, and LHRH.\n\nSource: \nChinese Hamster Ovary cell line, CHO-derived Gly110-Asn638 with a C-terminal 6-His tag\n\nSDS-PAGE:\n69kD, reducing conditions\n\nActivity:\nMeasured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC. \n\nSpecific Activity:\n (same/more than)60 pmoles/min/ug\n\nEndotoxin Level: (same/less than)1EU/1ug (LAL)\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

P9052-11C

Size

10ug

Form

Supplied as a liquid in Tris, sodium chloride, calcium chloride.

Purity

~90% (SDS-PAGE, reducing conditions).

References

1. Zhou, A. et al. (1999) J. Biol. Chem. 274:20745. 2. Lamango, N.S. et al. (1999) Arch. Biochem. Biophys. Preparation and Storage 362:275. 3. Zhu, X. and I. Lindberg (1995) J. Cell Biol. 129:1641. 4. Lamango, N. et al. (1996) Arch. Biochem. Biophys. 330:238. 5. Rouille?, Y. et al. (1995) Front. Neuroendocrinol. 16:322.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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