Supplier:
Alomone Labs Ltd.Cat no: P-105
PD 173212
Native voltage-gated Ca2+ channels (VGCC, CaV) are pharmacologically classified into at least five different subclasses (L-, N-, P-, Q-, and R-type), the characteristics of which are determined by the pore-forming alpha1 subunit. The subunit CaV2.2 (alpha1B) forms N-type Ca2+ channels, which are located primarily on presynaptic nerve terminals of central and peripheral neurons.
PD 173212 is a dipeptidyl-amine that acts as a N-type CaV channels blocker. It is the most active small molecule for N-type calcium channel blockade as it inhibits this channel with an IC50 of 36 nM in IMR-32 cells, as measured by using fluorescent technique. PD 173212 blocks also other CaV channels but to a lesser extent and only at higher concentrations.in vivo, it prevents tonic seizures in the audiogenic seizure model.
Ion Channel Modulator; Voltage - Gated Ca2+ Channel Blockers
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SPECIFICATIONS
Catalog Number
P-105
Size
5 mg
Purity
>99%
Concentration
10 nM - 10 uM
Shipping Temp
Room Temperature
Molecular Weight
599.9 da
SUPPLIER INFO
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