Home  >  Products  >  PDCD1, Recombinant, Mouse, aa22-170, His-tag (Programmed Cell Death Protein 1, Protein PD-1, hPD-1, CD279, PD1)

PDCD1, Recombinant, Mouse, aa22-170, His-tag (Programmed Cell Death Protein 1, Protein PD-1, hPD-1, CD279, PD1)

Cat no: 149778


Supplier: United States Biological
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Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of
Catalogue number: 149778
Size: 50ug
Form: Supplied as a liquid in 1X PBS, 0.1% SDS.
Purity: ~95%
References: 1. Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90. 2. Ishida Y, Agata Y, Shibahara K, et al. Induced expression of EPAC1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95. 3. Zhong X, Bai C, Gao W, et al. Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int. Immunol. 2004; 16:1181-8. 4. Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by the disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999; 11:141-51.

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