PDE4D, BioAssay(TM) Kit (PDE4D, cAMP-specific 3',5'-cyclic Phosphodiesterase 4D, DPDE3, PDE43, DPDE3)

Supplier:

United States Biological

Cat no: 137342

PDE4D, BioAssay(TM) Kit (PDE4D, cAMP-specific 3',5'-cyclic Phosphodiesterase 4D, DPDE3, PDE43, DPDE3)

Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE4D is a regulator of airway smooth-muscle contractility, and has been identified as a potential risk predictor for ischemic stroke. Additionally, PDE4D has been associated with asthma pathophysiology and bone formation. The PDE4D gene encodes at least 9 different isoforms.\n\nThe PDE4D inhibitor screening assay kit comes in a convenient 96-well format, with purified PDE4D3 enzyme, fluorescently labeled PDE4D substrate (cAMP), binding agent, and PDE assay buffer for 100 enzyme reactions. The key to the PDE4D Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE4D reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE4D for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization.\n\nIntended Use:\nDesigned for identification of inhibitors of PDE4D3 using fluorescence polarization.\n\nTest Principle:\nThe assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE4D to the binding agent.\n\nKit Components:\nPDE4D3 recombinant enzyme: 1x1ug\nFAM-Cyclic-3

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SPECIFICATIONS

Catalog Number

137342

Size

100Tests

References

1. Chandrasekaran A, et al.. Cell Signal. 2008; 20(1): 139-53.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

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