PDE7A, Active, Recombinant, Mouse, GST-Tag (High Affinity cAMP-specific 3',5'-cyclic Phosphodiesterase 7A, P2A, )

Supplier:

United States Biological

Cat no: 137348

PDE7A, Active, Recombinant, Mouse, GST-Tag (High Affinity cAMP-specific 3',5'-cyclic Phosphodiesterase 7A, P2A, )

Phosphodiesterase 7A, a cAMP-specific phosphodiesterase, has been shown to affect memory, T-cell functioning and emesis and has been implicated in depression. Two isoforms (PDE7A1 and PDE7A2) which differ at their N-terminal region, have been reported.\n\nSource:\nRecombinant corresponding to aa147-482 from mouse PDE7A, fused to GST-tag at N-terminal, expressed in Sf9 insect cells via a baculovirus expression system.\n\nMolecular Weight:\n~65kD\n\nSpecific Activity:\n~120pmol/min/ug\n\nApplications: \nSuitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

137348

Size

10ug

Form

Supplied as a liquid in 45mM Tris-HCl, pH 8.0, 124mM sodium chloride, 2.4mM potassium chloride, 18mM glutathione, 10% glycerol, 3mM DTT.

Purity

Purified (~22%)

References

1. Han, P., et al. (1998). Genomics Mar 1;48(2):275-6. 2. Yang, G., et al. (2003). J. Immunol. Dec 15;171(12):6414-20. 3. Yamamoto, et al. (2006) Eur. J. Pharmacol. Jul 10;541(1-2):106-14.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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